Trichloroethylene (TCE) is primarily associated with an increased risk of kidney cancer, which is strongly supported by scientific evidence, notes the Centers for Disease Control and Prevention | CDC (.gov) and the MN Dept. of Health. It is also linked to a higher risk of non-Hodgkin lymphoma and liver cancer.
There is strong evidence that trichloroethylene can cause kidney cancer in people and some evidence for trichloroethylene-induced liver cancer and malignant lymphoma. Lifetime exposure to trichloroethylene resulted in increased liver cancer in mice and increased kidney cancer and testicular cancer in rats.
The VA recognizes the dangers of TCE exposure and offers disability benefits to veterans with service-connected conditions linked to TCE. This includes veterans, reservists, and guardsmen who may have been exposed during service.
Prolonged or repeated exposure of trichloroethylene causes kidney cancer. Some evidence suggests that it may be associated with an increased risks of non-Hodgkin lymphoma and, possibly, liver cancer.
Increasing duration and cumulative exposure to TCE were associated with significantly increasing risk of MM when jobs given low confidence were considered unexposed.
Strong evidence, based on multiple human and experimental animal studies, shows that TCE exposure might cause autoimmune disease, including scleroderma, and a specific type of generalized hypersensitivity disorder.
HBV and HCV infections are associated with an increased risk of developing multiple myeloma, with HCV demonstrating a stronger association. These findings highlight the importance of screening and monitoring patients with chronic hepatitis for potential hematological malignancies, especially in high-risk regions.
Relatively short-term exposure of animals to trichloroethylene resulted in harmful effects on the nervous system, liver, respiratory system, kidneys, blood, immune system, heart, and body weight. Exposure to trichloroethylene in the workplace may cause scleroderma (a systemic autoimmune disease) in some people.
Whether because of an immune disease or immune suppressive drugs, lymphoma is more common in people with an impaired immune system. Certain infections can be connected with higher rates of lymphoma. These infections include Epstein-Barr virus infections and helicobacter pylori infections.
Health Hazard Summary
TCE can also damage the facial nerves, and it can cause skin rash. Heavy exposure can damage the liver and kidneys. TCE causes cancer in animals and may cause cancer in humans.
A 100% VA Disability Rating Is the Ultimate Level of Compensation and Protection: A 100% rating—often called the “holy grail” of VA benefits—means the VA has fully acknowledged the severity of your service-connected conditions.
Q: What Is the Most Hidden Disability? A: Professionals regard mental health disorders like depression, anxiety, bipolar disorder, and PTSD as the most hidden kinds of disabilities. People typically miss these conditions because they show no physical signs, and individuals hide them during social or work interactions.
Although trichloroethylene has many uses, the Department of Defense uses it mostly as an industrial cleaner to remove grease from metal parts. The use of trichloroethylene by the Department of Defense has been greatly reduced.
T-cell engagers (TCE) are synthetic full-length or fragment of immunoglobulin with a double affinity directed towards CD3 and tumor-associated antigens (TAA), mobilizing T-cells directly at the contact of tumor cells, resulting in an immediate anti-tumor immune response.
Trichloroethylene is used in many consumer products. Examples include typewriter correction fluids, paint removers, paint strippers, adhesives, spot removers, cleaning fluids for rugs, and metal cleaners.
Only 5–10% of all cancer cases can be attributed to genetic defects, whereas the remaining 90–95% have their roots in the environment and lifestyle.
NHL most often affects adults, but children can get it too. See Non-Hodgkin Lymphoma in Children. NHL usually starts in lymph nodes or other lymph tissue, but it can sometimes affect the skin.
While stress can impact overall health, there is no direct evidence linking stress alone to the development of non-Hodgkin's lymphoma. The disease's causes are multifactorial, involving genetic, environmental, and immune system factors.
Among immunosuppressive/immunomodulatory agents used for AIDs, the use of calcineurin inhibitors (HR 3.6, 95% CI 1.9–6.9), iguratimod (3.4, 1.7–6.9), or methotrexate (2.2, 1.4–3.6) was associated with a higher risk of lymphoma compared to non-users of the respective agents.
“The findings suggest that exposure to PCE may be the reason why one person develops liver disease while someone with the exact same health and demographic profile does not.” PCE is a human-made, colorless liquid used in dry cleaning, household goods and industrial settings to remove grease and for other purposes.
Aflatoxin B1 is the most potent hepatocarcinogen known, being about 1,000 times more powerful than butter yellow (p-dimethylaminoazobenzene) in rats.
There are also thought to be multiple environmental factors which may increase the risk of developing myeloma. These include exposure to certain types of industrial and agricultural chemicals, exposure to high doses of radiation, viruses and a weakened immune system.
Symptoms of multiple myeloma to look out for
The 2 known precursors to multiple myeloma, MGUS and smoldering myeloma, were first described by Kyle and Greipp in 1978 and 1980, respectively, as the presence of an M protein in the serum and/or excess bone marrow plasma cells in the absence of clinical evidence of either multiple myeloma or another ...